Definition
PDE5 inhibitors are a class of drugs — including sildenafil (Viagra) and tadalafil (Cialis) — that act peripherally to increase blood flow to erectile tissue by blocking phosphodiesterase type 5. On TruthTides, PDE5 inhibitors are referenced as the comparison class for PT-141 (Bremelanotide): unlike PDE5 inhibitors, PT-141 acts centrally on melanocortin receptors in the brain to modulate sexual desire rather than peripherally on blood flow. This distinction is clinically relevant because the two mechanisms address different components of sexual response.
Source: PT-141 peptide summary and FAQ
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