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Claim your listingPrasterone Vaginal (Intrarosa) · Clinical Reference
Frequently Asked Questions
What is prasterone?
Prasterone (Intrarosa) is an intravaginal preparation of dehydroepiandrosterone (DHEA). It is converted locally within vaginal tissue to estrogens and androgens, producing local symptom relief with minimal systemic hormonal exposure.
What is it FDA-approved for?
Prasterone is FDA-approved at 6.5 mg intravaginally once daily for moderate-to-severe dyspareunia due to menopause.
How is it different from vaginal estrogen?
Prasterone is a DHEA precursor that is metabolized intracellularly within vaginal cells (intracrinology). This produces local estrogenic and androgenic effects without measurable elevation of systemic estradiol or testosterone in most users, at standard doses.
Do I need a progestogen with it?
No. Trial data show no endometrial proliferation at the approved dose, and prasterone is not paired with a progestogen.
What are common side effects?
Vaginal discharge and abnormal Pap smear findings (typically benign) are the most commonly reported side effects.
How long does it take to work?
Symptom improvement is typically apparent within 4 weeks, with maximal benefit by 12 weeks of daily use.
Can I use it after breast cancer?
Use in breast cancer survivors is not established and remains off-label. Limited pharmacokinetic data suggest minimal systemic exposure, but oncology consultation is essential.
Can I get prasterone without a prescription?
No. Intrarosa is a prescription medication. Oral DHEA supplements sold OTC are not equivalent and are not a substitute for the FDA-approved intravaginal preparation.
How do I find a doctor who prescribes prasterone?
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