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Be the first physician listed for Medroxyprogesterone Acetate (MPA) in your area.
Claim your listingMedroxyprogesterone Acetate (MPA) · Clinical Reference
Frequently Asked Questions
What is medroxyprogesterone acetate used for?
Medroxyprogesterone acetate (MPA, Provera) is a synthetic progestin used for endometrial protection in combined HRT, treatment of secondary amenorrhea and abnormal uterine bleeding, and (as Depo-Provera) for contraception.
Is MPA still recommended in HRT?
It remains FDA-approved and effective for endometrial protection, but it is no longer the first-choice progestogen in most current guidelines. The WHI demonstrated increased breast cancer, VTE, stroke, and coronary events in the CEE + MPA arm, with subsequent observational data (E3N) suggesting micronized progesterone has a more favorable breast safety profile.
MPA is still appropriate for women who tolerate it, particularly in fixed-dose combination products.
Is MPA FDA-approved?
Yes. MPA is FDA-approved for endometrial protection in postmenopausal estrogen users, secondary amenorrhea, abnormal uterine bleeding, and contraception (Depo-Provera).
What are the main risks?
WHI data link continuous CEE + MPA to increased breast cancer risk, coronary heart disease, stroke, and VTE versus placebo. The absolute risks were small (roughly 8 extra breast cancers per 10,000 woman-years), but the relative comparison vs micronized progesterone is unfavorable.
Bone mineral density loss is a recognized concern with depot MPA used for contraception over several years.
How is MPA dosed for HRT?
Typical doses are 2.5 mg daily for continuous combined regimens or 5–10 mg for 12–14 days per month in sequential regimens. Dosing is determined by your prescriber based on bleeding patterns and tolerance.
What are common side effects?
Breakthrough bleeding (especially in the first 6 months), breast tenderness, bloating, mood changes, and headaches are the most common.
Can I get MPA without a prescription?
No. MPA is a prescription medication in all formulations.
How do I find a doctor who prescribes MPA?
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