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Frequently Asked Questions
What is hCG used for?
Human chorionic gonadotropin (hCG) mimics luteinizing hormone (LH) and is used clinically to: (1) preserve intratesticular testosterone and fertility in men on testosterone replacement therapy, (2) induce ovulation in assisted reproduction, and (3) treat selected forms of hypogonadotropic hypogonadism and cryptorchidism.
Is hCG FDA-approved?
Yes — for prepubertal cryptorchidism (not due to anatomic obstruction), selected cases of hypogonadotropic hypogonadism in males, and induction of ovulation/luteal support in assisted reproduction. It is not FDA-approved for weight loss; the FDA explicitly warns against OTC homeopathic hCG weight-loss products.
Why is hCG used with testosterone replacement?
Exogenous testosterone suppresses LH, which causes testicular atrophy and reduces intratesticular testosterone needed for sperm production. Concurrent low-dose hCG (typically 250–500 IU 2–3× weekly subcutaneously) maintains testicular size and preserves fertility for many men.
Does hCG cause weight loss?
No. Multiple randomized controlled trials and a Cochrane review found no evidence that hCG produces weight loss beyond the very-low-calorie diet it is typically paired with. The FDA prohibits OTC homeopathic hCG products marketed for weight loss.
What are the main risks?
Injection-site reactions, gynecomastia (from aromatization to estradiol), mood changes, headache, and (rarely) ovarian hyperstimulation syndrome in women undergoing fertility treatment. Risk of thromboembolism is reported with high-dose use.
How long does it take to work?
When used alongside TRT for fertility preservation, sperm parameters typically improve over 3–6 months. For hypogonadotropic hypogonadism, restoration of fertility may take 6–24 months and often requires combination with FSH analogues.
Can I get hCG without a prescription?
No. Injectable hCG is a prescription medication and is dispensed by licensed pharmacies (commercial or 503A compounding). Avoid OTC homeopathic hCG — these products do not contain pharmacologic hCG.
How do I find a doctor who prescribes hCG?
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