Definition
Growth hormone secretagogue is the mechanism class of Ipamorelin, which selectively stimulates GH release from the pituitary without significantly affecting cortisol or prolactin levels. Unlike GHRH analogs (CJC-1295, Sermorelin), secretagogues act on the ghrelin receptor to trigger pulsatile GH release. Ipamorelin is frequently combined with CJC-1295 for synergistic growth hormone optimization.
Source: Ipamorelin peptide summary and comparison table