Definition
GIP (glucose-dependent insulinotropic polypeptide) is an incretin hormone released from the small intestine that enhances insulin secretion in response to nutrient intake. On TruthTides, GIP is referenced as one of the two receptor targets of Tirzepatide, which is a dual GIP/GLP-1 receptor agonist FDA-approved as Mounjaro for type 2 diabetes and Zepbound for chronic weight management. The dual mechanism is thought to underlie Tirzepatide's superior HbA1c reduction and weight loss compared to GLP-1-only agents in head-to-head SURPASS trials.
Source: Tirzepatide peptide summary and FAQ
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