Peptide Comparison

    Semax vs Selank

    Semax and Selank are Russian-developed nootropic peptides. Semax is an ACTH(4-10) analog focused on neuroprotection and cognition; Selank is a tuftsin analog focused on anxiolytic and immunomodulatory effects.

    Semax

    Semax is a synthetic analog of ACTH(4-10), approved in Russia. It is not FDA-approved. See the TruthTides evidence and regulatory libraries for graded study summaries and citations.

    Semax Clinical Reference

    Selank

    Selank is a synthetic heptapeptide analog of tuftsin developed in Russia. Available human trial data is limited and largely Russian-language. See the TruthTides evidence library for graded study summaries and citations.

    Selank Clinical Reference

    Key Differences

    Category
    Semax
    Selank
    Structure
    Synthetic analog of ACTH(4-10).
    Synthetic heptapeptide analog of tuftsin.
    Primary effect
    Cognitive enhancement, neuroprotection, BDNF/NGF upregulation.
    Anxiolytic without sedation, immunomodulation, cognitive support.
    Approval
    Approved in Russia for stroke recovery and cognitive disorders.
    Approved in Russia.

    This comparison is informational and reflects content from TruthTides clinical reference documentation. It does not constitute medical advice. Only three peptides on TruthTides — semaglutide, tirzepatide, and tesamorelin — carry FDA approvals; many others are compounded or off-label. Consult a qualified physician before starting any peptide therapy.