Peptide Comparison

Ipamorelin vs CJC-1295

Ipamorelin and CJC-1295 are the two most common growth hormone secretagogues, and they're typically prescribed together. CJC-1295 raises baseline GHRH signaling; ipamorelin triggers pulsatile GH release.

Ipamorelin

Ipamorelin is a selective growth hormone secretagogue. See the TruthTides evidence library for graded study summaries and citations.

Ipamorelin Clinical Reference

CJC-1295

CJC-1295 is a synthetic GHRH analog. See the TruthTides evidence library for graded study summaries, pharmacokinetic data, and citations.

CJC-1295 Clinical Reference

Key Differences

Category

Ipamorelin

CJC-1295

Class

Selective GH secretagogue (ghrelin mimetic).

GHRH analog with DAC (Drug Affinity Complex) technology.

Mechanism

Stimulates pulsatile GH release without affecting cortisol or prolactin.

Sustains elevated GH and IGF-1 levels.

Typical use

Often stacked with CJC-1295 for synergistic effect.

Often stacked with ipamorelin; allows 1-2x weekly dosing.

This comparison is informational and reflects content from TruthTides clinical reference documentation. It does not constitute medical advice. Only three peptides on TruthTides — semaglutide, tirzepatide, and tesamorelin — carry FDA approvals; many others are compounded or off-label. Consult a qualified physician before starting any peptide therapy.

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