Peptide Comparison

    AOD-9604 vs Semaglutide

    AOD-9604 and semaglutide both target body composition, but through completely different mechanisms. AOD-9604 is a fragment of human growth hormone designed for lipolysis; semaglutide is a GLP-1 agonist that drives weight loss via appetite suppression and insulin regulation.

    AOD-9604

    AOD-9604 is a modified fragment (amino acids 177-191) of human growth hormone specifically designed for fat metabolism. It stimulates lipolysis and inhibits lipogenesis without the diabetogenic effects of full-length GH. It has been studied for obesity management and cartilage repair applications.

    AOD-9604 Clinical Reference

    Semaglutide

    Semaglutide is a GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and chronic weight management (Wegovy). Clinical trials demonstrate significant reductions in body weight and cardiovascular risk markers. It works by enhancing insulin secretion, suppressing glucagon, and reducing appetite.

    Semaglutide Clinical Reference

    Key Differences

    Category
    AOD-9604
    Semaglutide
    Mechanism
    Stimulates lipolysis, inhibits lipogenesis.
    GLP-1 agonist — appetite suppression and insulin regulation.
    FDA status
    GRAS status from FDA; not approved as a drug.
    FDA-approved as Ozempic and Wegovy.
    Typical weight loss
    Modest in clinical studies.
    15-17% body weight reduction in STEP trials.

    This comparison is informational and reflects content from TruthTides clinical reference documentation. It does not constitute medical advice. Only three peptides on TruthTides — semaglutide, tirzepatide, and tesamorelin — carry FDA approvals; many others are compounded or off-label. Consult a qualified physician before starting any peptide therapy.