What is this tanning peptide anyway?
If you have been hanging around the corners of the internet where people talk about biohacking their skin, you have probably heard of Melanotan II. It was originally developed at the University of Arizona.
Basically, the goal was to create a way to darken the skin without needing to sit under the sun for hours. It works as a non-selective melanocortin receptor agonist. That is a fancy way of saying it acts like a key that can unlock five different types of receptors in your body, from MC1R all the way to MC5R.
Why does it affect more than just skin color?
Because this peptide is non-selective, it does not just stick to the receptors that control skin color. It hits others too. This is where things get a bit messy.
- Skin darkening: It activates MC1R to stimulate melanogenesis, which is the process of your skin making more pigment.
- Appetite and sex: It also hits the MC3R and MC4R receptors. This means it can affect your hunger and your sexual function.
- Oil production: It even touches MC5R, which is linked to your sebaceous glands, also known as the oil-making parts of your skin.
What do the experts say?
Scientists have confirmed that this peptide does indeed cause tanning. However, because it activates so many different receptors, it causes a lot of off-target effects. These are basically extra things happening in your body that you might not have signed up for.
There are also some serious questions that haven't been answered yet. For example, scientists are still concerned about whether it might promote melanoma, which is a dangerous type of skin cancer. Because of these risks, the FDA and TGA have issued safety communications about it.
Where does the science stand?
Right now, this peptide has an Evidence Grade: C. This means the data is a bit thin or conflicting. It is not approved by regulatory agencies, and both the FDA and TGA have warned people about using it.
Scientists are still working on this one — turns out the human body is complicated. Who knew?
This is a great one to bring up with your doctor. You can find peptide-experienced physicians in our Find a Doctor directory.
Disclaimer: This content is sourced exclusively from TruthTides clinical reference data and does not constitute medical advice.
Referenced Peptides
This content was generated from TruthTides clinical reference data. It does not constitute medical advice. Always consult a qualified healthcare provider.